Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ROCK2 All Species: 32.73
Human Site: S258 Identified Species: 60
UniProt: O75116 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75116 NP_004841.2 1388 160900 S258 V G T P D Y I S P E V L K S Q
Chimpanzee Pan troglodytes P61584 1003 117506 G38 P I P K A F V G N Q L P F V G
Rhesus Macaque Macaca mulatta XP_001096931 1524 173861 S394 V G T P D Y I S P E V L K S Q
Dog Lupus familis XP_540083 1519 175559 S389 V G T P D Y I S P E V L K S Q
Cat Felis silvestris
Mouse Mus musculus P70336 1388 160567 S258 V G T P D Y I S P E V L K S Q
Rat Rattus norvegicus Q62868 1379 159417 S249 V G T P D Y I S P E V L K S Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505615 1400 161955 S229 K Q H S F F K S D Q W N W D S
Chicken Gallus gallus XP_419954 1438 166280 S307 V G T P D Y I S P E V L K S Q
Frog Xenopus laevis NP_001154860 1372 159002 S244 V G T P D Y I S P E V L K S Q
Zebra Danio Brachydanio rerio NP_777288 1375 159755 S244 V G T P D Y I S P E V L K S Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W1B0 1637 186706 P269 G T P D Y I S P E I L R A M E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P92199 1173 135756 A207 I S G H I K L A D F G T C V K
Sea Urchin Strong. purpuratus XP_001198244 1323 154677 E230 G N G Q Y G R E C D W W S V G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 43.3 90.4 87.8 N.A. 96.6 95.7 N.A. 82.3 86.8 82 75.2 N.A. 24.1 N.A. 34.2 47.4
Protein Similarity: 100 56.9 90.8 89.5 N.A. 98.3 97.4 N.A. 86.2 91.9 89.9 86.6 N.A. 45.2 N.A. 52.8 64.9
P-Site Identity: 100 0 100 100 N.A. 100 100 N.A. 6.6 100 100 100 N.A. 0 N.A. 0 0
P-Site Similarity: 100 26.6 100 100 N.A. 100 100 N.A. 20 100 100 100 N.A. 13.3 N.A. 26.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 8 0 0 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 0 0 8 0 0 % C
% Asp: 0 0 0 8 62 0 0 0 16 8 0 0 0 8 0 % D
% Glu: 0 0 0 0 0 0 0 8 8 62 0 0 0 0 8 % E
% Phe: 0 0 0 0 8 16 0 0 0 8 0 0 8 0 0 % F
% Gly: 16 62 16 0 0 8 0 8 0 0 8 0 0 0 16 % G
% His: 0 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 8 0 0 8 8 62 0 0 8 0 0 0 0 0 % I
% Lys: 8 0 0 8 0 8 8 0 0 0 0 0 62 0 8 % K
% Leu: 0 0 0 0 0 0 8 0 0 0 16 62 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % M
% Asn: 0 8 0 0 0 0 0 0 8 0 0 8 0 0 0 % N
% Pro: 8 0 16 62 0 0 0 8 62 0 0 8 0 0 0 % P
% Gln: 0 8 0 8 0 0 0 0 0 16 0 0 0 0 62 % Q
% Arg: 0 0 0 0 0 0 8 0 0 0 0 8 0 0 0 % R
% Ser: 0 8 0 8 0 0 8 70 0 0 0 0 8 62 8 % S
% Thr: 0 8 62 0 0 0 0 0 0 0 0 8 0 0 0 % T
% Val: 62 0 0 0 0 0 8 0 0 0 62 0 0 24 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 16 8 8 0 0 % W
% Tyr: 0 0 0 0 16 62 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _